Cadherins and epithelialmesenchymal transition EMT
Cadherins play an essential role in maintaining the integrity of the epithelial layer. Cadherins mediate tight cell-cell junctions and are integral components of adherens junctions and desmosomes.150 The large extracellular domain forms a calcium-dependent homophilic interaction with cadherin molecules on neighboring cells while the cytoplasmic domain associates with alpha-, beta-, and gamma-catenins. These molecules interact, in turn, with the actin cytoskeleton and intracellular signaling...
Microtubule Targeting Agents
B R Hearn, S J Shaw, and D C Myles, Kosan Biosciences, Hayward, CA, USA 2007 Elsevier Ltd. All Rights Reserved. 7.04.1 Introduction Microtubule Targeting Agents 81 7.04.1.1 Microtubule Dynamics and the Cell Cycle 81 7.04.2 Inhibitors of Microtubule Assembly 82 7.04.2.1 Inhibitors Targeting the Vinca Alkaloid Binding Domain 82 7.04.2.1.1 Nonpeptide vinca site inhibitors 82 7.04.2.1.2 Peptides and depsipeptides 86 7.04.2.2 Inhibitors Targeting the Colchicine Alkaloid Binding Domain 88 7.04.2.2.1...
References 1
1. Parkin, D. M. Lancet Oncol. 2001, 2, 533-543. 2. Karnofsky, D. A. Ann. NY Acad. Sci. 1958, 68, 899-914. 3. Banerji, U. Judson, I. Workman, P. Molecular Targets. In Handbook of Anticancer Pharmacokinetics and Pharmacodynamics Figg, W D., Mcleod, H. L., Eds. Humana Press New Jersey, 2004, pp 1-27. 4. Beelen, A. Lewis, L. D. Clinical Pharmacology Overview. In Handbook of Anticancer Pharmacokinetics and Pharmacodynamics Figg, W D., Mcleod, H. L., Eds. Humana Press New Jersey, 2004, pp 111-127....
Cancer Biology
M-S Maira, M A Pearson, D Fabbro, and C Garc a-Echeverr a, Novartis Institutes for BioMedical Research, Basel, Switzerland 2007 Elsevier Ltd. All Rights Reserved. 7.01.2 Cancer Epidemiology 2 7.01.2.1 Molecular Cancer Epidemiology 3 7.01.2.2 Risk Factors and Cancer 3 7.01.2.3 Cancer Screening, Diagnosis, and Prevention 5 7.01.2.3.1 Genetic markers 5 7.01.2.3.2 Diagnostic and prognostic biomarkers 5 7.01.3 Available Treatment Modalities 6 7.01.3.4 Photodynamic Therapy 7 7.01.4 Treatment Options...